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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

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Related Experiment Video

Updated: May 9, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Global Rheumatology Registries and Cohorts.

Manuel F Ugarte-Gil1, Guillermo J Pons-Estel2, Graciela S Alarcón3

  • 1Grupo Peruano de Enfermedades Autoinmunes Sistémicas, Universidad Científica del Sur, Lima, Peru; Department of Rheumatology, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru.

Rheumatic Diseases Clinics of North America
|May 7, 2026
PubMed
Summary

Global rheumatology registries have advanced systemic autoimmune disease research over 40 years. Achieving equitable global representation in these cohorts remains an ongoing challenge for comprehensive disease understanding.

Keywords:
CohortsEpidemiologyEthnicityJuvenile idiopathic arthritisOutcomesRegistriesRheumatologySystemic lupus erythematosus

Related Experiment Videos

Last Updated: May 9, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Area of Science:

  • Rheumatology
  • Epidemiology
  • Autoimmune Diseases

Background:

  • Global rheumatology registries and cohorts have been established over four decades.
  • These initiatives have significantly improved the understanding of systemic autoimmune disease epidemiology.
  • They have also facilitated the development of new classification criteria, outcome measures, and disease activity assessments.

Purpose of the Study:

  • To review the development and impact of global rheumatology registries and cohorts.
  • To highlight the progress made in describing systemic autoimmune diseases.
  • To identify the need for enhanced global representation in research efforts.

Main Methods:

  • Review of existing literature and data from global rheumatology registries and cohorts.
  • Analysis of the contributions of these registries to classification criteria and outcome measures.
  • Assessment of global representation and identification of gaps.

Main Results:

  • Registries have enhanced the description of systemic autoimmune disease epidemiology.
  • New classification criteria, outcome measures, and disease activity states have been proposed.
  • Despite progress, significant gaps in global representation persist, particularly from low- and middle-income countries.

Conclusions:

  • Global rheumatology registries are crucial for advancing the study of systemic autoimmune diseases.
  • Continued efforts are needed to ensure inclusive global participation and data collection.
  • The examples provided offer a potential roadmap for achieving truly global coverage in rheumatology research.