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Related Experiment Video

Updated: May 9, 2026

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
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In Vivo Visualization of the Round Window Niche Veil using Photon-Counting Detector CT.

Kaden M Neuberger1, Paul F Farnsworth2, John I Lane2

  • 1From the Department of Radiology (K.M.N., P.F.F., J.I.L., S.L., J.C.B.), Otolaryngology- Head and Neck Surgery (M.L.C.), Division of Clinical Trials and Biostatistics (B.A.K.), Mayo Clinic, Rochester, MN, USA and Department of Otorhinolaryngology-Head and Neck Surgery (D.M.), University Hospital of Verona, Italy. Neuberger.kaden@mayo.edu.

AJNR. American Journal of Neuroradiology
|May 7, 2026
PubMed
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Photon-counting-detector CT can visualize the round window niche veil (RWNV), a barrier to intratympanic medication. This imaging may help determine if the round window niche is patent.

Area of Science:

  • Medical Imaging
  • Otolaryngology
  • Radiology

Background:

  • The round window niche veil (RWNV) is an anatomic barrier potentially hindering intratympanic medication efficacy.
  • RWNV can be caused by thickened middle ear mucosa or fibrosis, obstructing the round window niche.

Purpose of the Study:

  • To characterize the in vivo capability of photon-counting-detector CT (PCD-CT) to visualize the RWNV.
  • To assess the utility of PCD-CT in identifying potential barriers to intratympanic medication delivery.

Main Methods:

  • 80 temporal bones were scanned using PCD-CT.
  • Two neuroradiologists independently reviewed scans, scoring for partial/complete RWNV, absence of RWNV, or niche opacification.

Main Results:

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Last Updated: May 9, 2026

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  • PCD-CT visualized partial or complete RWNV in 43.8% of ears.
  • RWNV was not visualized in 48.8% of ears despite a clear round window.
  • High inter-rater reliability (kappa=0.81) was observed in RWNV visualization.

Conclusions:

  • PCD-CT demonstrates capability for in vivo visualization of the RWNV.
  • PCD-CT may aid in assessing round window niche patency, informing treatment strategies.