Related Experiment Video
Updated: May 9, 2026
![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Benzoxazine-Promoted Copper Catalyst for the Activation of the Benzylic C-O Bond: A Homolytic Cleavage without Light
Yanjun Zhu1, Zhen Zhang1, Nan Wang1
1Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China.
Abstract:
The benzoxazine and copper combination demonstrated a unique reactivity, which could activate the C-O bond of benzylic alcohols or benzyl ether at mild temperature and natural conditions. This novel reactivity leads to the product of benzylic ethers with water as the byproduct. Mechanistic investigation showed evidence to support that the reaction undergoes a radical pathway.
More Related Videos
05:34Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
08:56Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Related Concept Videos
Reactions at the Benzylic Position: Oxidation and Reduction
Reduction of Benzene to Cyclohexane: Catalytic Hydrogenation
Oxidative Cleavage of Alkenes: Ozonolysis
Ozone is a symmetrical bent molecule stabilized by a resonance structure.
Nucleophilic Aromatic Substitution: Elimination–Addition
Reactions at the Benzylic Position: Halogenation
Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism