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Related Concept Videos

Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

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Related Experiment Video

Updated: May 9, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
08:53

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

Renal failure isn't just a nephrologist problem.

Gennaro Cice1

  • 1Department of Cardiology, Policlinico Casilino, Rome, Italy.

European Heart Journal Supplements : Journal of the European Society of Cardiology
|May 8, 2026
PubMed
Summary

Chronic kidney disease (CKD) affects 700 million people globally, far exceeding the number of dialysis patients. Early detection and prevention are crucial to address this public health crisis.

Keywords:
Cardiovascular RiskChronic Kidney DiseaseNephroprotectionPreventionSGLT2 Inhibitors

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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Related Experiment Videos

Last Updated: May 9, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
08:53

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Area of Science:

  • Nephrology
  • Public Health
  • Internal Medicine

Background:

  • Uraemic patients are commonly misperceived as only those on dialysis, who represent a small fraction of the total uraemic population.
  • Chronic kidney disease (CKD) affects approximately 700 million individuals globally, constituting a significant public health issue.
  • CKD presents a substantial economic burden and high mortality rate, with 2.6 million deaths estimated in 2017.

Purpose of the Study:

  • To highlight the discrepancy between the public perception of uraemia and the actual prevalence of renal dysfunction.
  • To emphasize the urgent need for new strategies focusing on early detection and prevention of CKD.
  • To advocate for a conceptual shift in viewing CKD as a multisystem condition rather than solely a nephrological disorder.

Main Methods:

  • Analysis of global epidemiological data on kidney dysfunction.
  • Review of mortality and economic burden statistics associated with CKD.
  • Conceptual analysis of CKD's classification and required medical attention.

Main Results:

  • Renal dysfunction impacts approximately 10% of the population in industrialized nations, totaling around 700 million people.
  • CKD is a leading cause of mortality, responsible for an estimated 2.6 million deaths annually.
  • The current approach to CKD is insufficient, necessitating a broader, multisystem perspective.

Conclusions:

  • CKD is a widespread global health concern, affecting a much larger population than commonly perceived.
  • Effective management of CKD requires a paradigm shift towards early detection, prevention, and a collaborative, multisystem approach.
  • Internists, cardiologists, diabetologists, and general practitioners must be involved in CKD management alongside nephrologists.