Related Experiment Video
Updated: May 9, 2026
09:56
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
Peripheral T-Cell Lymphomas in Southern Taiwan: Epidemiology, Treatment Patterns, and Long-Term Outcomes
Bo-Yu Huang1, Li-Chang Chang1, Sheng-Yen Hsiao2
1Division of Hematology Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan.
Ejhaem
|May 8, 2026
Summary
Peripheral T-cell lymphomas (PTCLs) in Taiwan show East Asian subtype prevalence and high-risk features. Salvage hematopoietic stem cell transplantation (HSCT) after relapse significantly improves survival for PTCL patients.
Area of Science:
- Hematology
- Oncology
- Epidemiology
Background:
- Peripheral T-cell lymphomas (PTCLs) are aggressive cancers with varied geographic distribution and limited data from Taiwan.
- Understanding regional epidemiology and treatment patterns is crucial for improving patient outcomes.
Purpose of the Study:
- To characterize the epidemiology, treatment patterns, and survival outcomes of PTCL patients in southern Taiwan.
- To identify prognostic factors and evaluate the role of hematopoietic stem cell transplantation (HSCT) in PTCL management.
Main Methods:
- Retrospective cohort study of 249 PTCL patients diagnosed between 2010 and 2024 at two major centers in southern Taiwan.
- Analysis of subtype distribution, clinical characteristics, treatment strategies, and survival data.
- Multivariable analysis to identify independent prognostic factors.
Main Results:
- Predominant subtypes included nodal T follicular helper cell lymphoma, angioimmunoblastic type (22%), extranodal NK/T-cell lymphoma (21%), and PTCL-NOS (15%).
- Most patients presented with advanced stage (71%), bone marrow involvement (47%), and elevated LDH (64%).
- Median overall survival was 17.6 months; salvage HSCT after relapse improved survival compared to chemotherapy alone.
Conclusions:
- PTCL in Taiwan exhibits East Asian subtype prevalence and frequently presents with high-risk features, leading to poor prognosis.
- ECOG performance status, LDH levels, extranodal involvement, and age are key adverse prognostic factors.
- Salvage HSCT is essential for achieving durable survival in relapsed PTCL patients, highlighting the need for improved therapeutic strategies.
