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Updated: May 9, 2026
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Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
Pan-Immune-Inflammation Value Predicts Disease Activity and Ocular Involvement in Behçet's Disease: A Case-Control
Eman M Shawky1, Maha S I Abdelrahman1, Sara Farrag1
1Department of Rheumatology, Rehabilitation and Physical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mediterranean Journal of Rheumatology
|May 8, 2026
Summary
Pan-immune-inflammation value (PIV) and other inflammatory markers are elevated in Behçet's disease (BD). PIV effectively identifies active ocular involvement in BD patients.
Area of Science:
- Rheumatology
- Clinical Immunology
- Hematology
Background:
- Behçet's disease (BD) diagnosis is challenging due to a lack of specific laboratory markers.
- Inflammatory markers derived from complete blood counts may offer diagnostic and prognostic value in BD.
Purpose of the Study:
- To evaluate the diagnostic utility of pan-immune-inflammation value (PIV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) in Behçet's disease.
- To investigate the correlation between these inflammatory markers and disease activity in BD patients.
Main Methods:
- A case-control study involving 40 BD patients and 40 healthy controls.
- Calculation of PIV, NLR, PLR, and MLR from complete blood counts.
- Clinical evaluation and disease activity scoring using BDCAF and ESR.
Main Results:
- BD patients exhibited significantly higher levels of PIV, NLR, PLR, and MLR compared to healthy controls.
- PIV showed a positive correlation with BDCAF and erythrocyte sedimentation rate.
- PIV was significantly elevated in patients with active ocular and musculoskeletal involvement, demonstrating high sensitivity and specificity for active ocular disease.
Conclusions:
- PIV is positively correlated with Behçet's disease activity.
- PIV is a superior biomarker compared to other studied ratios for detecting active ocular involvement in BD.
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