Pan-Immune-Inflammation Value Predicts Disease Activity and Ocular Involvement in Behçet's Disease: A Case-Control...

Behçet's disease (BD) lacks distinctive laboratory findings, so this study aimed at evaluating the pan-immune-inflammation value (PIV), neutrophil to lymphocyte ratio (NLR), platelets to lymphocytes ratio (PLR), and monocytes to lymphocytes ratio (MLR) in BD in addition to investigating their relationship with disease activity.

This case control study included 40 BD patients and 40 age and sex matched healthy volunteers. Complete clinical evaluation and disease activity scoring were conducted. Complete blood count was done for all participants with calculation of PIV, NLR, PLR and MLR.

BD patients showed significantly higher PIV, NLR, PLR and MLR level than healthy participants (p=0.04, 0.04, < 0.001 and 0.007, respectively). PIV showed significant positive correlation with BDCAF and erythrocyte sedimentation rate (p= 0.025 and 0.039, respectively). We detected a significantly greater PIV in patients with active ocular and musculoskeletal disease (p=0.001 and 0.037 respectively). At a cutoff of 238.26, PIV yielded an AUC of 0.81 (95% CI, p=0.001), with 83% sensitivity and 82% specificity for detecting active ocular involvement.

PIV showed positive correlation with disease activity. PIV is superior to other studied blood cells derived ratios in detecting active ocular involvement in BD patients.