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Related Concept Videos

Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at the...

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Related Experiment Video

Updated: May 9, 2026

Stereotaxic Surgical Approach to Microinject the Caudal Brainstem and Upper Cervical Spinal Cord via the Cisterna Magna in Mice
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Internal connectivity of the mouse mesocortical ring and functional implications.

Luis Puelles1,2, Elena Garcia-Calero3,4

  • 1Departamento de Anatomía Humana y Psicobiología, Facultad de Medicina, Universidad de Murcia, Campus de Ciencias de la Salud, Murcia, 30120, España.

Brain Structure & Function
|May 8, 2026
PubMed
Summary

The mammalian mesocortex (MCx) ring, a newly defined brain region, shows interconnected sectors. The medial posterior orbitary cortex plays a central role in this network, suggesting integrative functions within the mesocortex.

Keywords:
SelfConnectomeLimbic systemPosterior orbitary cortexPsychopathy

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Area of Science:

  • Neuroscience
  • Brain Anatomy
  • Molecular Biology

Background:

  • The mammalian mesocortex (MCx) is a recently redefined brain region forming a ring between the allocortex and isocortex.
  • It is characterized by 46 selective gene markers and low myelin content, influencing its function and susceptibility to disorders.
  • Despite a shared molecular profile, MCx sectors like the posterior orbitary cortex, cingulate cortex, and insula have distinct characteristics.

Purpose of the Study:

  • To analyze the internal connectivity within the mesocortical ring.
  • To understand the functional relationships between different mesocortical sectors.

Main Methods:

  • Utilized anterograde connectivity experiments from the Allen Institute for Brain Science database.
  • Investigated the projection patterns within the mesocortical ring.

Main Results:

  • Demonstrated that different sectors of the MCx ring are multiply interconnected.
  • Identified the medial posterior orbitary cortex as a key hub, projecting to and receiving from all other mesocortical sectors.
  • These interconnections suggest potential integrative functions within the MCx.

Conclusions:

  • The mesocortical ring exhibits significant internal connectivity, supporting integrated brain functions.
  • The medial posterior orbitary cortex appears to hold a higher hierarchical position within the mesocortical network.