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Updated: Aug 5, 2026

Visualization of Cortical Modules in Flattened Mammalian Cortices
Published on: January 22, 2018
Regional Functional Molecular Profiles Within the Mammalian Cortex: A Commentary on Limbic Mesocortex
Luis Puelles1,2, Elena Garcia-Calero1,2
1Departamento de Anatomía Humana y Psicobiología, Facultad de Medicina, Universidad de Murcia, Campus de Ciencias de la Salud, Murcia, España.
Abstract:
Two lateral mouse brain sagittal sections labeled, respectively, for Lypd1 (A) and Kcnab3 (B). (A) Lypd1 labels positively cortical Layers 2 and 5 (less heavily), but only at limbic mesocortical sites, forming the limbic ring that separates the unlabeled isocortex (IsoCx) from the unlabeled hippocampal and olfactory allocortex (Hi, Sub, ERh; OlfCx). The limbic ring is marked twice as the insula (Ins, MCx) and the postrhinal area (PoRh, MCx). (B) Kcnab3, contrarily, labels selectively various layers of the isocortex (IsoCx) and the hippocampal allocortex (Hi, Sub, ERh) but leaves unlabeled selectively the insula (Ins, MCx) and postrhinal (PoRh, MCx) areas of the limbic mesocortical ring, being thus a negative marker for this sort of cortex.
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