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Updated: May 9, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
Bi-objective location-allocation model of interventions in high drug consumption areas incorporating X topic modeling
Kevin Palomino1,2, Carmen Berdugo3, Jorge Acuña4,5
1Department of Industrial Engineering, Universidad del Norte, Km 5 via Puerto Colombia, Barranquilla, Atlántico, 100190, Colombia. krpalomino@uninorte.edu.co.
Abstract:
The Comprehensive Policy for the Prevention and Care of Psychoactive Substance Use in Colombia aims to improve the care provided to people, families, and communities at risk or struggling with psychoactive substance use through prevention and mitigation programs. The effectiveness of these programs depends on both population participation and access to intervention centers. This study proposes a bi-objective integer programming model within a location-allocation framework to support policy decisions under budget constraints. To estimate drug-related risk, we integrate sentiment analysis from social media data (X, formerly Twitter) as a key input into the optimization model. Specifically, negative sentiment derived from posts is used to inform the spatial distribution of risk between locations. The model simultaneously minimizes population-level risk and distance to services, while ensuring equitable coverage based on multidimensional poverty and rurality. The proposed approach was applied to real-world data from Atlántico. The results demonstrated that the bi-objective model achieved an average coverage of 24.67% of the population within a 40 km radius, effectively balancing service accessibility between high-risk urban areas and underserved rural zones. Compared to a population-based heuristic, which achieved only 8.85% coverage and excluded 22 of 23 locations, the proposed model significantly improved equity in service distribution. Furthermore, complementary topic modeling using Latent Dirichlet Allocation (LDA) revealed key themes in public discourse, including drug cartels, addiction risks, and social impacts, providing valuable information to support tailored communication and community engagement strategies for new intervention centers.
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