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Updated: May 11, 2026
09:47
Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
Published on: December 9, 2022
Retinal development.
Elizabeth Fishman-Williams1, Anna LA Torre1
1Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA, United States.
Handbook of Clinical Neurology
|May 9, 2026
Summary
This chapter explores vertebrate retinal development, detailing molecular signals and cellular interactions from optic vesicle morphogenesis to cell-type generation. Understanding these processes is crucial for addressing retinal dystrophies and congenital eye defects.
Area of Science:
- Developmental biology
- Neuroscience
- Ophthalmology
Background:
- The vertebrate retina exhibits complex cellular coordination for light signal transduction.
- Retinal development involves intricate molecular signals and precise cellular interactions.
Purpose of the Study:
- To provide an in-depth exploration of key stages in vertebrate retinal development.
- To investigate molecular pathways governing retinal cell specification, differentiation, and fate maintenance.
- To examine the clinical implications of disrupted retinal development, including dystrophies and congenital defects.
Main Methods:
- Review of molecular pathways in retinal development.
- Analysis of spatial patterning and cell fate determination.
- Examination of neurogenesis timing and regulation.
- Drawing on research from model organisms (mice, zebrafish).
Main Results:
- Detailed elucidation of optic vesicle morphogenesis and retinal domain establishment.
- Identification of molecular orchestrators for cell specification, proliferation, and differentiation.
- Understanding of mechanisms maintaining cell fate during morphogenetic movements.
- Insights into how developmental disruptions lead to retinal diseases.
Conclusions:
- Vertebrate retinal development is a tightly regulated process involving complex molecular and cellular events.
- Understanding these mechanisms is vital for comprehending and potentially treating retinal dystrophies and congenital eye defects.
- Research in model organisms provides critical insights into human retinal development and disease.
Keywords:
Anterior neural plateNeurogenesisRetinal progenitor cellTissue morphogenesisVertebrate retinaMore Related Videos
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