Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Clot Retraction and Fibrinolysis

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.

Introduction to Hemostasis

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...

Extrinsic and Intrinsic Pathways of Hemostasis

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...

Formation of the Platelet Plug

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same authorSame journal

Long-term follow-up after surgery for congenital anomalies: A time to complication analysis.

Seminars in pediatric surgery·2026

Same author

Shifting pediatric operative experience in the era of fellowship expansion: A national analysis of residents, fellows, and the match.

Journal of pediatric surgery·2026

Same author

Feeding Practices in Simple Gastroschisis: Insights into Practice Variation from a Multidisciplinary Survey.

Journal of pediatrics. Clinical practice·2026

Same author

Cellular Therapy for In Utero Repair of Myelomeningocele (the CuRe trial): neurosurgical repair video.

Neurosurgical focus: Video·2026

Same author

"You Die or You Get Better": A Community-Engaged Narrative Inquiry Photovoice Study Examining Conceptualizations of Health-Seeking Behavior and Healthcare Encounters Among Older Adult (Im)Migrants in Wisconsin, the United States.

Public health nursing (Boston, Mass.)·2026

Same author

Post-extraction management of esophageal button battery injuries in children: A scoping review of imaging, ICU admission, and NPO practices.

Journal of pediatric surgery·2026

Search research articles

Related Experiment Video

Updated: May 11, 2026

Simple and Effective Procedure for Hemostasis in Mouse Arteries

Simple and Effective Procedure for Hemostasis in Mouse Arteries

Published on: November 28, 2025

Quick clots for tiny spots: Hemostatic agents in action.

Elizabeth Reynolds¹, Francois Trappey¹

¹Department of Surgery, Brooke Army Medical Center, Fort Sam Houston, TX, USA.

Seminars in Pediatric Surgery

|May 9, 2026

Summary

This summary is machine-generated.

Topical hemostatic agents, advanced by the U.S. military, improve bleeding control. However, evidence for their use in pediatric patients is limited, requiring further investigation.

Keywords:

Hemostasis Military Pediatrics Wound dressing

More Related Videos

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Related Experiment Videos

Last Updated: May 11, 2026

Simple and Effective Procedure for Hemostasis in Mouse Arteries

Simple and Effective Procedure for Hemostasis in Mouse Arteries

Published on: November 28, 2025

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Area of Science:

Emergency medicine
Trauma surgery
Pediatric critical care

Background:

Topical hemostatic agents have advanced hemorrhage control in adults.
Military development has driven innovation in these agents.
Limited data exists on pediatric use.

Purpose of the Study:

To review key topical hemostatic agents, focusing on prehospital and intraoperative applications.
To discuss mechanisms of action and performance in diverse settings.
To evaluate the current evidence for pediatric use.

Main Methods:

Narrative review of topical hemostatic agents.
Emphasis on agents available in prehospital and combat settings.
Inclusion of intraoperative agents for military and civilian use.

Main Results:

Several topical hemostatic agents are available for prehospital and intraoperative use.
Mechanisms of action vary, impacting performance in different environments.
Pediatric efficacy and safety data remain scarce.

Conclusions:

Topical hemostatic agents offer significant benefits for hemorrhage control.
Further research is crucial to establish safety and efficacy in pediatric populations.
Bridging the knowledge gap in pediatric hemostasis is essential for improved patient outcomes.