Related Experiment Video

Updated: May 12, 2026

Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
11:22

Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue

Published on: August 17, 2016

Gallium-Containing Agents for Tumor Diagnosis and Therapy: Current Status and Future Prospects

Yue Han1, Qi Li1, Yufeng Zheng2

  • 1Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Beijing Key Laboratory for Intelligent Biomanufacturing and Regeneration of Craniofacial Tissues & NHC Key Laboratory of Digital Stomatology, Beijing, China.

Small (Weinheim an Der Bergstrasse, Germany)
|May 10, 2026
PubMed

Insights

Gallium (Ga)-containing agents are promising for tumor theranostics, offering advanced imaging and therapeutic capabilities. Future research should focus on AI, personalized treatments, and targeted delivery for improved clinical translation.

Area of Science:

  • Oncology
  • Radiochemistry
  • Medical Imaging

Background:

  • Gallium (Ga)-containing agents exhibit unique properties for tumor theranostics.
  • Recent research explores their interactions with the tumor microenvironment and antitumor mechanisms.

Purpose of the Study:

  • To review the current status of Ga-containing agents in tumor diagnosis and therapy.
  • To cover their imaging/therapeutic mechanisms, clinical applications, advantages, and limitations.

Main Methods:

  • Literature review of Ga-containing radiopharmaceuticals, therapeutic compounds, and multifunctional formulations.
  • Analysis of clinical applications, particularly 68Ga-labeled probes for cancer diagnosis.
  • Examination of therapeutic mechanisms including DNA metabolism interference, immune regulation, and angiogenesis inhibition.

Main Results:

  • 68Ga-labeled probes are standard for diagnosing prostate cancer, neuroendocrine tumors, and other malignancies.
  • Ga therapeutic agents impact DNA metabolism, tumor immunity, and angiogenesis.
  • Ga agents demonstrate significant potential in both diagnostic and therapeutic oncology.

Conclusions:

  • Ga-containing agents offer significant advantages in tumor theranostics.
  • Future clinical translation requires advancements in AI-assisted imaging, personalized theranostics, targeted delivery, and multicenter studies.
Keywords:
diagnosisgalliumtheranosticstherapytumor

More Related Videos

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging07:26

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging

Published on: November 20, 2018

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment10:33

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment

Published on: April 25, 2025

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...