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Updated: May 12, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
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Strategies for formaldehyde sensing and their applications.

Xing Han1, Qing-Ling Su1, Jin-Fa Chen1

  • 1Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Eco-environmental Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China.

Advances in Colloid and Interface Science
|May 10, 2026
PubMed
Summary

Formaldehyde (HCHO) sensing is crucial for public health due to its toxicity. This review details various HCHO detection strategies, focusing on mechanisms and materials for improved sensor design.

Keywords:
Formaldehyde detectionFunctional materialsSelectivity and sensitivitySensing applicationsSensing mechanisms

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Area of Science:

  • Environmental Science
  • Analytical Chemistry
  • Materials Science

Background:

  • Formaldehyde (HCHO) is a pervasive toxic contaminant and a known human carcinogen.
  • Its widespread presence poses significant risks to public health and environmental safety.
  • Reliable HCHO sensing technologies are essential for monitoring and mitigation.

Purpose of the Study:

  • To systematically review and classify various strategies for formaldehyde sensing.
  • To analyze sensing mechanisms, materials design, and performance characteristics.
  • To discuss practical applications and future prospects for HCHO sensor development.

Main Methods:

  • Classification of HCHO sensing systems based on diverse interaction mechanisms (e.g., imine formation, oxidation, hydrogen bonding).
  • Detailed discussion of representative sensing platforms: optical probes, electrochemical transducers, and metal oxide semiconductor (MOS) chemiresistors.
  • Comprehensive analysis of sensitivity, selectivity, response characteristics, and limitations.

Main Results:

  • Overview of HCHO sensing strategies, highlighting mechanisms like Schiff base formation and supramolecular assembly.
  • Evaluation of various sensor types, including optical, electrochemical, and MOS-based systems.
  • Summary of practical applications in environmental monitoring, food safety, and bioimaging.

Conclusions:

  • Effective HCHO sensor design requires optimizing capture mechanisms and signal transduction.
  • Advancements in materials and understanding interaction mechanisms are key to enhanced performance.
  • Future prospects focus on developing sensors for real-world deployment meeting stringent demands.