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Published on: May 26, 2023
Initial clinical experience with the paragon balloon guide catheter in mechanical thrombectomy: a multicenter
Ho Jun Yi1, Dong-Seong Shin2, Bum-Tae Kim2
1Department of Neurosurgery, Soonchunhyang University Bucheon Hospital, Bucheon, the Republic of Korea; Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, the Republic of Korea; Department of Neurosurgery, Hangang Sacred Heart Hospital, Hallym University, Seoul, the Republic of Korea.
The Paragon balloon guide catheter (BGC) improves mechanical thrombectomy (MT) for large vessel occlusion (LVO) by enabling more distal tip placement, leading to a higher first pass effect (FPE). This enhances procedural efficiency in stroke treatment.
Area of Science:
- Neurology
- Interventional Neuroradiology
- Medical Devices
Background:
- Large vessel occlusion (LVO) stroke requires timely mechanical thrombectomy (MT).
- Balloon guide catheters (BGCs) are crucial for MT, aiding in flow arrest and device delivery.
- Optimizing BGC use can improve MT procedural efficiency and outcomes.
Purpose of the Study:
- To evaluate the efficacy of the Paragon balloon guide catheter (BGC) in mechanical thrombectomy (MT) for large vessel occlusion (LVO).
- To compare procedural outcomes between the Paragon BGC and other BGCs in LVO patients.
- To identify predictors of first pass effect (FPE) in MT.
Main Methods:
- Retrospective review of MT procedures for LVO between October 2023 and September 2025.
- Comparison of patients treated with Paragon BGC (n=41) versus other BGCs (n=83).
- Propensity score matching (PSM) and multivariable analyses to assess outcomes and predictors of FPE.
Main Results:
- The Paragon BGC group showed significantly higher rates of distal BGC tip placement (53.7% vs. 8.4%) and FPE (58.5% vs. 48.2%).
- Lower aspiration catheter delivery failure rates were observed with the Paragon BGC (14.6% vs. 26.5%).
- PSM analysis confirmed higher distal tip placement and FPE rates with the Paragon BGC (59.5% vs. 48.6%).
Conclusions:
- The Paragon BGC is associated with improved procedural efficiency in MT for LVO.
- Distal BGC tip placement and the use of Paragon BGC are independent predictors of achieving FPE.
- The Paragon BGC facilitates more effective MT for LVO, potentially improving patient outcomes.
