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Related Concept Videos

Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...

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A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
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A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

Gut Microbial Metabolism in Colorectal Cancer.

Yaowei Qin1, Zhen Feng2, Zhonghua Cheng3

  • 1Shanghai Pudong Hospital and Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Methods in Molecular Biology (Clifton, N.J.)
|May 10, 2026
PubMed
Summary
This summary is machine-generated.

Gut microbes and their metabolites impact colorectal cancer (CRC) development and progression. This review explores microbial metabolism

Keywords:
Cancer-associated fibroblastsColorectal cancerFecal immunochemical testGut microbial metabolismIntestinal microbiota

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Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures
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Last Updated: May 12, 2026

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
08:14

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures
08:53

Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures

Published on: November 3, 2014

Area of Science:

  • Microbiology
  • Oncology
  • Metabolomics

Background:

  • The human gut harbors diverse microorganisms producing metabolites vital for homeostasis.
  • Gut microbial metabolites are implicated in various intestinal diseases, notably colorectal cancer (CRC).
  • CRC is a leading cause of cancer death, characterized by high metastatic potential.

Purpose of the Study:

  • To review mechanisms linking gut microbial metabolism to colorectal cancer.
  • To outline clinical applications of gut microbiota and metabolites in CRC.
  • To identify research gaps and future directions in the field.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of studies on gut microbiota, metabolism, and CRC.
  • Discussion of translational prospects for biomarkers and therapeutics.

Main Results:

  • Gut microbiota and their metabolites influence colorectal carcinogenesis via multiple pathways.
  • Microbial metabolites can serve as potential biomarkers for CRC detection.
  • Gut microbiota and their metabolites show promise as therapeutic agents for CRC.

Conclusions:

  • Understanding the gut microbiome's metabolic role is crucial for CRC prevention and treatment.
  • Further research is needed to fully elucidate mechanisms and translate findings into clinical practice.
  • Targeting gut microbial metabolism offers novel strategies for CRC management.