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Updated: May 12, 2026

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Published on: October 12, 2017

Clinical Study on the Association Between Lipoprotein(a) Levels and Prognosis in Patients With Acute Ischemic Stroke

Xinyi Chen1,2, Yueyu Zhang1,2, Yi Tang1,2

  • 1Department of Neurology, Hefei Hospital Affiliated to Anhui Medical University (Hefei Second People's Hospital), Hefei, China.

Brain and Behavior
|May 11, 2026
PubMed

Insights

Elevated Lipoprotein(a) (Lp(a)) levels predict poor outcomes in acute ischemic stroke (AIS) patients. Combining Lp(a) with NIHSS scores improves prognostic accuracy for better risk stratification.

Area of Science:

  • Neurology
  • Cardiology
  • Biomarkers

Background:

  • Lipoprotein(a) (Lp(a)) is a recognized cardiovascular risk factor.
  • The prognostic value of Lp(a) in acute ischemic stroke (AIS) patients is not well-established.
  • This study aims to clarify the association between Lp(a) levels and 3-month functional outcomes in AIS.

Purpose of the Study:

  • To investigate the association between Lp(a) levels and 3-month functional outcomes in AIS patients.
  • To determine if Lp(a) is an independent predictor of poor prognosis after AIS.
  • To explore the threshold effect of Lp(a) on AIS outcomes and its combined predictive value with NIHSS.

Main Methods:

  • A retrospective cohort study involving 175 AIS patients.
  • Functional outcomes assessed using the modified Rankin Scale (mRS) at 3 months (mRS > 2 indicating poor outcome).
  • Logistic regression, threshold effect models, and ROC curve analysis were employed to analyze Lp(a) and NIHSS predictive performance.

Main Results:

  • Elevated Lp(a) levels were independently associated with poor 3-month prognosis (OR = 1.09, p = 0.004).
  • A significant threshold effect for Lp(a) was observed at 31.2 mg/dL, with levels above this associated with a 79% increased risk of poor outcomes (p = 0.0398).
  • The combined Lp(a)-NIHSS model demonstrated superior predictive accuracy (AUC = 0.6820) compared to either marker alone.

Conclusions:

  • Lp(a) serves as a stable, independent predictor of poor 3-month functional outcomes in AIS patients.
  • A clear threshold effect of Lp(a) at 31.2 mg/dL was identified, impacting prognosis.
  • Integrating Lp(a) with NIHSS enhances prognostic accuracy, highlighting Lp(a)'s utility in early risk stratification for AIS.
Abstract

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