Related Experiment Videos

Impact of comorbidities on D-dimer and CRP in covid-19 patients: A comparative retrospective analysis

Jyoti Shukla1, Ritesh Yadav2, Girish Dubey2

  • 1Department of Biochemistry, Shrimant Rajmata Vijayaraje Scindia Medical College, Shivpuri, Madhya Pradesh, India.

Bioinformation
|May 11, 2026
PubMed

Insights

Higher inflammatory markers like C-reactive protein (CRP) and D-dimer were observed in multimorbid COVID-19 patients. Monitoring these biomarkers is crucial for managing patients with comorbidities.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Clinical Medicine

Background:

  • The COVID-19 pandemic highlighted the importance of inflammatory biomarkers for prognosis.
  • Understanding the impact of comorbidities on these markers is vital for patient management.

Purpose of the Study:

  • To investigate the correlation between comorbidity burden and inflammatory markers (CRP and D-dimer) in hospitalized COVID-19 patients.
  • To assess differences in CRP and D-dimer levels across non-comorbid, comorbid, and multimorbid patient groups.

Main Methods:

  • Analysis of 100 hospitalized COVID-19 patients at a tertiary care center.
  • Categorization of patients based on comorbidity status: non-comorbid, comorbid, and multimorbid.
  • Measurement and comparison of C-reactive protein (CRP) and D-dimer levels among the groups.

Main Results:

  • Multimorbid COVID-19 patients exhibited significantly higher levels of both D-dimer and CRP compared to comorbid and non-comorbid groups (p<0.05).
  • The study included a mean age of 53.18 ± 15.48 years with a male predominance (63%).

Conclusions:

  • Elevated inflammatory biomarkers (CRP and D-dimer) are associated with increased comorbidity burden in COVID-19 patients.
  • Monitoring these biomarkers aids in early identification of disease progression and guides targeted therapeutic interventions in patients with comorbidities.

Keywords:
C-reactive protein (CRP)COVID-19D-dimercomorbiditiesinflammatory markers

Related Concept Videos

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...