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Transfusion requirements in acute coronary syndrome patients undergoing thrombolysis or anticoagulation: A

Subhash Chandra1, Varun Singh Sisodia2, Prachi Jain Rai1

  • 1Department of Cardiology, UPUMS, Saifai, Etawah, India.

Bioinformation
|May 11, 2026
PubMed

Bleeding complications and associated transfusion requirements remain a significant concern in patients with Acute Coronary Syndrome (ACS) undergoing anticoagulation or thrombolysis, yet data on transfusion needs and risk factors in resource-limited settings are limited. Therefore, it is of interest to assess transfusion requirements in 85 patients with Acute Coronary Syndrome (ACS) undergoing anticoagulation or thrombolysis at UPUMS, Saifai, from December 2024 to April 2025. Major bleeding requiring transfusion occurred in 4.7% (n=4) of patients, predominantly due to gastrointestinal sources (50%). The mean transfusion requirement was 2 units of packed red blood cells per bleeding event. Independent risk factors for major bleeding were age >65 years, chronic kidney disease and triple therapy (antiplatelet + anticoagulant + fibrinolytic). Bleeding was associated with significantly higher 30-day mortality (25% versus 5% in non-bleeders), highlighting the need for individualized antithrombotic strategies in ACS management.

Keywords:
Acute Coronary Syndrome (ACS)anticoagulationchronic kidney diseasetherapeutic strategiesthrombolysis

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