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Advanced Gastric Cancer Presenting as a Giant Subepithelial Lesion: A Case Report
Ji Sun1, Qian Wang2, Yuemei Hu3
1Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Shanghai China.
Clinical Case Reports
|May 11, 2026
Summary
Gastric cancer can mimic subepithelial lesions. Intraoperative frozen section analysis is recommended for suspected gastric gastrointestinal stromal tumors (GISTs) lacking preoperative pathological confirmation to avoid incorrect surgery.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Gastric cancer can present as a subepithelial lesion.
- Gastrointestinal stromal tumors (GISTs) are a type of mesenchymal tumor that can arise in the stomach.
- Preoperative diagnosis of gastric subepithelial lesions can be challenging.
Purpose of the Study:
- To highlight the diagnostic challenge of gastric subepithelial lesions.
- To emphasize the importance of intraoperative frozen section analysis for suspected gastric GISTs.
- To guide surgical decision-making in cases of ambiguous gastric lesions.
Main Methods:
- Review of cases with gastric subepithelial lesions.
- Analysis of preoperative diagnostic methods.
- Evaluation of intraoperative frozen section analysis utility.
Main Results:
- Gastric cancer can exhibit a subepithelial lesion-like presentation.
- Definitive preoperative pathological confirmation for gastric GISTs is not always achieved.
- Intraoperative frozen section analysis aids in differentiating GISTs from other gastric lesions.
Conclusions:
- Gastric subepithelial lesions require careful preoperative evaluation.
- Intraoperative frozen section analysis is crucial for suspected gastric GISTs without preoperative diagnosis.
- This approach helps prevent unnecessary or inappropriate surgical interventions.
