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Updated: May 12, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
Published on: August 4, 2023
Longitudinal changes in coagulation-fibrinolysis in patients with traumatic brain injury within seven days after
Xinlong Dong1,2, Nanyu Yao1, Limin Zhang3
1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Abstract:
Traumatic brain injury (TBI)-induced coagulopathy is associated with poor outcomes of patients, but its progression remains poorly understood. We longitudinally collected peripheral venous blood samples from patients with TBI 24 h, 3 days, and 7 days after injury, and analyzed the samples for conventional blood and conventional coagulation tests, thromboelastography, coagulation factor activity, platelet activity, and levels of extracellular vesicles through laboratory tests. By detecting longitudinal changes in the coagulation-fibrinolysis, we found that TBI patients were in a state of hyperfibrinolysis within 24 h after injury, but transitioned to a hypercoagulable state on the 7th day after injury. And, the concentrations of extracellular vesicles continued to increase from 24 h to 7 days after injury. We identified the early changes in TBI-induced coagulopathy, namely that TBI patients undergo a transition from a hyperfibrinolytic state to a hypercoagulable state within 24 h to 7 days post-injury.
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