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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Analytic Considerations for the Evaluation of Tuberculosis Preventative Therapy Effectiveness Among People Living
Lindsey M Schader1, Seth Zissette2, Fadimatu Mishara3
1Biostatistics and Bioinformatics Emory University.
Abstract:
Despite data from randomized trials demonstrating the benefits of tuberculosis preventive treatment (TPT) for people living with HIV, there remain gaps in the large-scale programmatic provision of TPT and understanding of its impact. The PROTECT study is a multi-country study that aims to evaluate the effectiveness of TPT programs on tuberculosis incidence and mortality. The study leverages electronic health records, which poses challenges in the design, analysis, and interpretation of the data. In this work, we describe the general analysis approach that will be adopted across countries for evaluation of the effectiveness of TPT programs.
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