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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Related Experiment Video

Updated: May 12, 2026

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
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Published on: October 21, 2022

Coefficient-metric gradient-based digital wavefront correction for full-field swept-source optical coherence

Guozheng Xu1, Jem Love1, Thomas J Smart2

  • 1Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, United Kingdom.

Biomedical Optics Express
|May 11, 2026
PubMed
Summary
This summary is machine-generated.

We developed CoMGrad, a GPU-accelerated method for digital wavefront correction in full-field swept source optical coherence tomography (FF-SS-OCT). This novel technique significantly speeds up aberration correction in retinal imaging, improving efficiency tenfold.

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12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Area of Science:

  • Ophthalmology
  • Biomedical Optics
  • Medical Imaging

Background:

  • Full-field swept source optical coherence tomography (FF-SS-OCT) enables rapid, depth-resolved volumetric imaging.
  • Phase stability in FF-SS-OCT allows for post-processing digital wavefront correction.
  • Conventional wavefront correction methods are accurate but inefficient.

Purpose of the Study:

  • To introduce CoMGrad, a novel GPU-accelerated optimization method for digital wavefront correction in FF-SS-OCT.
  • To enhance the time efficiency of aberration correction in FF-SS-OCT imaging.

Main Methods:

  • Developed CoMGrad, a coefficient-metric gradient-based optimization technique.
  • Utilized the differentiability of Zernike coefficients to image quality metrics.
  • Implemented reverse-mode automatic differentiation and the Adam optimizer for efficiency.
  • Conducted theoretical analysis and in vivo aberration correction tests on human retinas.

Main Results:

  • CoMGrad achieves a tenfold increase in time efficiency for wavefront correction compared to traditional coordinate search methods.
  • Demonstrated effective aberration correction in in vivo human retinal imaging.
  • Validated the theoretical performance of the CoMGrad algorithm.

Conclusions:

  • CoMGrad offers a significantly faster and efficient approach to digital wavefront correction for FF-SS-OCT.
  • This method holds promise for improving the speed and practicality of high-resolution retinal imaging.
  • The GPU-accelerated optimization accelerates post-processing in optical coherence tomography.