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Updated: May 12, 2026
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Coefficient-metric gradient-based digital wavefront correction for full-field swept-source optical coherence
Guozheng Xu1, Jem Love1, Thomas J Smart2
1Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, United Kingdom.
None:
Full-field swept source optical coherence tomography (FF-SS-OCT) achieves fast acquisition of depth-resolved volumetric data. It preserves the phase stability across en face features, which enables digital wavefront correction during post-processing. Traditional digital wavefront correction methods, such as coordinate search, are reliable but time-consuming. We present CoMGrad, a novel GPU-accelerated coefficient-metric gradient-based optimisation method for digital wavefront correction for FF-SS-OCT. CoMGrad utilises the differentiability of the mapping from the Zernike coefficients to the image quality metric. Reverse-mode automatic differentiation and the Adam optimiser were used to increase time efficiency. Theoretical analysis and in vivo aberration correction tests on human retinas demonstrate that CoMGrad provides more than a tenfold increase in time efficiency compared to coordinate search.
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