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Updated: May 12, 2026

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The YAP1-NPM1 nuclear complex regulates MYC and reveals a targetable oncogenic node

Abdulrahman M Dwead1,2, Marwah M Al-Mathkour1,3, Maxim Khanov4

  • 1Department of Biological Sciences and Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA.

Iscience
|May 11, 2026
PubMed
Summary

Yes-associated protein 1 (YAP1) and nucleophosmin 1 (NPM1) form a complex in prostate cancer. Inhibiting NPM1 disrupts this axis, suppressing cancer growth and offering new therapeutic strategies.

Keywords:
biochemistrybiological sciencescancercell biology

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