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Related Experiment Video

Updated: May 12, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
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Biomimetic Microfibers for Myelin-Enhancer Screening and Neural Regeneration.

Lili Quan1, Akiko Uyeda1, Atsushi Sekiguchi2

  • 1Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan.

Cyborg and Bionic Systems (Washington, D.C.)
|May 11, 2026
PubMed
Summary

Researchers developed a new biomaterial to study myelin wrapping and found dimemorfan, a sigma-1 receptor agonist, significantly enhances remyelination and functional recovery in demyelinated conditions.

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Last Updated: May 12, 2026

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Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Area of Science:

  • Neuroscience
  • Biomaterials Science
  • Pharmacology

Background:

  • Remyelination, crucial for neural function, is hindered by a lack of quantitative systems to study oligodendrocyte wrapping of axons.
  • Understanding the mechanisms and pharmacology of myelin wrapping is essential for developing treatments for demyelinating diseases.

Purpose of the Study:

  • To develop a bioengineered platform for high-content quantification of oligodendrocyte wrapping.
  • To identify compounds that enhance myelin wrapping and promote remyelination.
  • To investigate the therapeutic potential of identified compounds in demyelinating conditions.

Main Methods:

  • Created a bioengineered microfiber platform mimicking neurite architecture and surface chemistry for oligodendrocyte wrapping assays.
  • Screened compounds to identify enhancers of myelin wrapping.
  • Tested the efficacy of lead compounds in demyelinated mouse models and human induced pluripotent stem cell (iPSC)-derived oligodendrocytes.
  • Utilized population-level magnetic resonance imaging (MRI) to assess white matter volume changes.

Main Results:

  • The bioengineered platform enabled high-content quantification of oligodendrocyte wrapping.
  • Dimemorfan, a sigma-1 receptor agonist, was identified as a potent enhancer of myelin wrapping.
  • Dimemorfan accelerated remyelination and functional recovery in demyelinated mice.
  • Dimemorfan promoted myelin wrapping by human iPSC-derived oligodendrocytes.
  • MRI revealed increased white matter volume in dimemorfan-treated subjects.

Conclusions:

  • The developed biomaterial platform is effective for myelin quantification and drug discovery in regeneration.
  • Dimemorfan shows therapeutic potential for promoting remyelination and functional recovery.
  • Sigma-1 receptor modulation is a viable strategy for enhancing myelin repair.