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Related Experiment Video

Updated: May 12, 2026

Clinical Anthropometrics and Body Composition from 3-Dimensional Optical Imaging
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Clinical Anthropometrics and Body Composition from 3-Dimensional Optical Imaging

Published on: June 7, 2024

Predicting MASLD in People With HIV Using Anthropometric Measures: A Multicenter Cross-Sectional Study.

Jihad Slim1, Murad Qirem2, Paul Bellafiore2

  • 1Department of Infectious Diseases, NewYork Medical College, Valhalla, New York, USA.

Open Forum Infectious Diseases
|May 11, 2026
PubMed
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This summary is machine-generated.

Waist circumference (WC) shows fair ability to detect fatty liver disease in people with HIV (PWH). This simple measure may help target screening for metabolic dysfunction-associated steatotic liver disease (MASLD) in routine care.

Area of Science:

  • Hepatology
  • Infectious Diseases (HIV/AIDS)
  • Metabolic Disorders

Background:

  • Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing concern in people with human immunodeficiency virus (PWH).
  • Standard anthropometric measures like BMI and waist circumference (WC) are used for metabolic risk assessment, but their accuracy for MASLD in PWH is unclear.

Purpose of the Study:

  • To evaluate the diagnostic performance of various anthropometric and metabolic indices for detecting hepatic steatosis in PWH.
  • To compare the predictive accuracy of body mass index (BMI), WC, hip circumference, waist-to-hip ratio (WHR), and visceral adiposity index (VAI) for MASLD in this population.

Main Methods:

  • A multicenter cross-sectional study involving 256 adults with HIV.
  • Transient elastography with controlled attenuation parameter (CAP) was used to define hepatic steatosis (CAP ≥248 dB/m).
Keywords:
AnthropometricHIVHuman Immunodeficiency VirusMASLDMetabolic dysfunction-associated steatotic liver disease

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Last Updated: May 12, 2026

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  • Receiver operating characteristic (ROC) curve analyses were performed to assess the diagnostic performance of different indices, stratified by sex.

    • Main Results:

    • Waist circumference (WC) demonstrated the highest diagnostic discrimination for CAP-defined steatosis (AUC 0.769), outperforming BMI and hip circumference.
    • WHR and VAI showed weaker performance in detecting hepatic steatosis.
    • In sex-stratified analyses, WC was the best predictor in males, while BMI, WC, hip circumference, and VAI showed similar performance in females.

    Conclusions:

    • Simple anthropometric measures, especially WC, have fair ability to identify hepatic steatosis in PWH.
    • WC can potentially facilitate targeted screening for fatty liver disease in PWH within routine HIV care settings.