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Related Concept Videos

Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...

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Related Experiment Video

Updated: May 12, 2026

Micropipette Aspiration of Substrate-attached Cells to Estimate Cell Stiffness
10:31

Micropipette Aspiration of Substrate-attached Cells to Estimate Cell Stiffness

Published on: September 27, 2012

Microenvironment stiffness regulates cell cycle.

Shiqi Gu1, Yang Yang2, Bingxue Lin1

  • 1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Cell Cycle (Georgetown, Tex.)
|May 11, 2026
PubMed
Summary

Extracellular matrix (ECM) stiffness, a physical property of the cellular microenvironment, significantly influences cell cycle progression. This review explores how ECM stiffness impacts cell cycle control and disease development.

Keywords:
Microenvironment stiffnesscell cyclecell proliferationmitosis

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Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses
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Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses

Published on: March 25, 2015

Related Experiment Videos

Last Updated: May 12, 2026

Micropipette Aspiration of Substrate-attached Cells to Estimate Cell Stiffness
10:31

Micropipette Aspiration of Substrate-attached Cells to Estimate Cell Stiffness

Published on: September 27, 2012

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses
07:45

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses

Published on: March 25, 2015

Area of Science:

  • Biophysics
  • Cell Biology
  • Mechanobiology

Background:

  • The cell cycle regulates cell proliferation in health and disease.
  • Extracellular matrix (ECM) stiffness is a key physical regulator of cellular behavior.
  • ECM stiffness and cell cycle are implicated in diseases like cancer and fibrosis.

Purpose of the Study:

  • To review current findings on how microenvironmental stiffness regulates the cell cycle.
  • To elucidate the mechanotransduction pathways involved.
  • To identify limitations and future research directions.

Main Methods:

  • Literature review of mechanotransduction pathways.
  • Analysis of studies across different cell types and stiffness ranges.
  • Discussion of disease implications.

Main Results:

  • ECM stiffness is a critical regulator of cell cycle progression.
  • Mechanotransduction pathways link physical cues to cell cycle control.
  • ECM stiffness changes dynamically during disease progression.

Conclusions:

  • Understanding the interplay between ECM stiffness and the cell cycle is crucial for disease insights.
  • Further research is needed to fully elucidate these mechanobiological mechanisms.
  • Targeting ECM stiffness may offer therapeutic potential in related diseases.