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Cellular Adaptation II: Hypertrophy01:26

Cellular Adaptation II: Hypertrophy

Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy: physiological...

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Masseter and Pterygoid Muscle Hypertrophy in a Cat.

Jennifer B Alterman1,2, Cynthia M Bell3, Erin E Epperly4

  • 1Dentistry and Oral Surgery Department, BluePearl Veterinary Partners (where research was conducted), Midvale, UT, USA.

Journal of Veterinary Dentistry
|May 11, 2026
PubMed
Summary

This report details the first veterinary case of benign masseter and pterygoid muscle hypertrophy in a cat. This uncommon condition caused facial swelling, diagnosed via clinical, imaging, and histopathologic evaluation.

Keywords:
case reportmasseter muscle hypertrophypterygoid muscle hypertrophy

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Area of Science:

  • Veterinary Medicine
  • Comparative Pathology

Background:

  • Benign hypertrophy of masticatory muscles, specifically the masseter and pterygoid muscles, is a rare condition documented in human medical literature.
  • Concurrent hypertrophy of medial and lateral pterygoid muscles alongside masseter muscle hypertrophy is infrequently reported in humans.
  • The etiology of benign masticatory muscle hypertrophy remains largely unknown in both human and veterinary contexts.

Purpose of the Study:

  • To report the first documented case of benign masseter and pterygoid muscle hypertrophy in a feline patient.
  • To describe the clinical presentation, diagnostic process, and histopathologic findings of this rare condition in veterinary medicine.

Main Methods:

  • Clinical examination of a 6-year-old neutered male cat presenting with unilateral facial swelling.
  • Diagnostic imaging, including radiography and/or ultrasonography, to assess the facial structures.
  • Histopathologic examination of biopsied or excised muscle tissue to confirm the diagnosis of benign hypertrophy.

Main Results:

  • A diagnosis of benign hypertrophy of the masseter and pterygoid muscles was confirmed through integrated clinical, imaging, and histopathologic data.
  • The feline patient exhibited left-sided facial swelling attributed to the enlarged masticatory muscles.
  • This case represents the initial description of this specific condition within the veterinary literature.

Conclusions:

  • Benign masseter and pterygoid muscle hypertrophy, though rare, should be considered in the differential diagnosis for feline facial swelling.
  • This case highlights the importance of comprehensive diagnostic approaches in identifying uncommon conditions in veterinary patients.
  • Further research may elucidate the underlying causes and potential treatment strategies for this condition in animals.