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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
RBM15/IGF2BP2-PTPRH m6A regulatory axis in non-small cell lung cancer
Keyue Qiu1,2, Xiaoxiao Zheng3, Hongxiang Li1,2
1Department of Thoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, 315000, China.
Cellular Oncology (Dordrecht, Netherlands)
|May 11, 2026
Summary
This study reveals a new mechanism where RBM15 and IGF2BP2 stabilize PTPRH mRNA via m6A modification, driving non-small cell lung cancer (NSCLC) progression. This RBM15/IGF2BP2-PTPRH axis presents a potential therapeutic target for NSCLC.
Area of Science:
- Oncology
- Molecular Biology
- Epigenetics
Background:
- Non-small cell lung cancer (NSCLC) is a major global cancer-related mortality cause.
- Identifying novel molecular drivers and therapeutic targets for NSCLC is critical.
- This research focuses on protein tyrosine phosphatase receptor type H (PTPRH) and its epitranscriptomic regulation in NSCLC.
Purpose of the Study:
- To investigate the role and regulation of PTPRH in NSCLC.
- To elucidate the epitranscriptomic mechanism involving N6-methyladenosine (m6A) modification in PTPRH regulation.
- To identify the RBM15/IGF2BP2-PTPRH axis as a potential therapeutic target.
Main Methods:
- Integrated analysis of The Cancer Genome Atlas and Gene Expression Omnibus datasets.
- Validation of PTPRH expression in clinical NSCLC specimens and correlation with clinicopathological features.
- In vitro and in vivo functional assays to assess PTPRH effects on tumor progression.
- Investigation of m6A modification, RBM15, and IGF2BP2 roles in PTPRH mRNA stability.
Main Results:
- PTPRH is overexpressed in NSCLC and correlates with poor prognosis.
- PTPRH promotes proliferation, migration, invasion, and angiogenesis, while inhibiting apoptosis.
- RBM15-mediated m6A modification and IGF2BP2 binding stabilize PTPRH mRNA, driving oncogenic functions.
Conclusions:
- A novel RBM15/IGF2BP2-PTPRH axis regulates PTPRH mRNA stability via m6A modification in NSCLC.
- This axis promotes NSCLC progression and represents a potential therapeutic target.
- The study enhances understanding of post-transcriptional regulation in lung cancer.
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