Related Experiment Video
Updated: May 24, 2026

Non-Intubated Video-Assisted Thoracoscopic Surgery
Published on: May 26, 2023
Exploratory research on drugs after lung surgery based on real-world data from the FDA adverse event reporting system
Qiaoling Pan1, Hang Chen1, Hanbo Pan2
1Department of Thoracic surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang Province, P. R. China.
Backgrounds:
Lung surgery is the most common surgery in thoracic surgery, but postoperative dyspnea, cough, palpitations, and chest pain seriously affect the quality of life of patients and hinder their postoperative recovery.
Methods:
To reveal the potential correlation between drugs and adverse events, we used disproportionation analysis to calculate the ROR and PRR values of the top 30 reported cases of dyspnea, cough, palpitations, and chest pain, respectively. In addition, we defined high and medium ROR signaling drugs after lung surgery by generating Venn diagram and calculated the PRR of all drugs used to treat pulmonary hypertension to explore the correlation between pulmonary arterial hypertension drugs and these four symptoms.
Results:
We identified the top 30 drugs that are most related to dyspnea, cough, palpitations, and chest pain, and defined 4 high ROR signaling drugs after lung surgery, and 10 medium ROR signaling drugs after lung surgery. Among them, 3 high ROR signaling drugs are drugs for treating pulmonary hypertension (PH). Subsequently, further analysis revealed that it is the basic drug attribute of treating PH that can easily cause these four common symptoms after lung surgery.
Conclusion:
Our study provides a list of high and medium ROR signaling drugs drugs for postoperative patients with lung surgery and clarifies the potential correlation between the properties of drugs for treating pulmonary arterial hypertension and dyspnea, cough, palpitations, and chest pain, providing a theoretical basis for the medication of postoperative patients.
Related Concept Videos
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Drug Regulation
Clinical Trials: Overview
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Clinical Trials
There are four phases in a clinical trial. A phase one...
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions