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The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

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Related Experiment Video

Updated: May 13, 2026

2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum
07:50

2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum

Published on: December 8, 2023

A Bioactive Component from Aconitum pendulum Attenuates Rheumatoid Arthritis-Related Inflammation in Rats via

Dan Dong1, Si-Si Jiang1, Hao Yu2

  • 1School of Pharmacy, Qinghai MinZu University.

Journal of Visualized Experiments : Jove
|May 11, 2026
PubMed
Summary
This summary is machine-generated.

Aconitum pendulum root compounds, particularly smirnotine A, show potential for treating rheumatoid arthritis (RA). Smirnotine A targets the PI3K/Akt pathway to reduce inflammation, validating traditional uses.

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Last Updated: May 13, 2026

2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum
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Published on: December 8, 2023

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Published on: May 12, 2023

Area of Science:

  • Phytochemistry
  • Immunology
  • Pharmacology

Background:

  • Traditional Chinese medicine utilizes Aconitum pendulum roots for rheumatic diseases and arthralgia.
  • A. pendulum is recognized across ethnic medical systems for treating sprains and inflammatory conditions.

Purpose of the Study:

  • To investigate the anti-inflammatory mechanisms of six compounds isolated from A. pendulum against rheumatoid arthritis (RA).
  • To provide a scientific basis for the traditional application of A. pendulum in managing RA.

Main Methods:

  • Employed network pharmacology, molecular docking, ELISA, H&E staining, q-PCR, and Western blot.
  • Conducted both in vitro and in vivo experiments to assess compound efficacy.

Main Results:

  • Smirnotine A, a key compound, demonstrated significant alleviation of RA symptoms.
  • Smirnotine A was found to target the PI3K/Akt signaling pathway, effectively suppressing inflammatory responses.

Conclusions:

  • Smirnotine A possesses anti-inflammatory properties beneficial for RA treatment.
  • The study elucidates the mechanistic action and material basis for A. pendulum's traditional use in managing RA.