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Updated: May 13, 2026

Iridium(III) Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II
Published on: July 7, 2015
Aggregation Induced Emission Active Organoiridium(III) Complex Based on Piperazine-Substituted 1,10-phenanthroline
Nimisha Kashyap1, Khanindram Baruah1, Jogat Gogoi1
1Department of Chemistry, North-Eastern Hill University, Shillong, Meghalaya, India.
Abstract:
In this work, the rational design and synthesis of a new green emissive cyclometalated iridium(III) complex-based AIEgen 1[PF6] containing a piperazine-substituted 1,10-phenanthroline ligand is presented. 1[PF6] was fully characterized by NMR spectroscopic and ESI-MS spectrometric studies. The photophysical properties of 1[PF6] were examined by UV-vis and PL spectroscopic studies. The electronic transitions associated with the absorption and emission spectra of 1[PF6] in acetonitrile were predicted using standard computational methods. While 1[PF6] was weakly emissive in acetonitrile, a significantly enhanced emissive pattern was observed in water and polyethylene glycol (PEG), indicating the aggregation-induced emission (AIE) phenomenon. The formation of aggregated particles from 1[PF6] was evidenced by UV-vis spectroscopy, DLS, SEM, and TEM studies. Interestingly, the pH-responsive modulation of the luminescence intensity of 1[PF6] in the aqueous medium, as well as in the fabricated portable paper strips, highlighted a higher emission profile in the slightly acidic medium (pH: 3-5) with a reduced emission intensity pattern towards the neutral to alkaline medium. Moreover, the biocompatibility of 1[PF6] was assessed in a representative cervical cancer cell line (HeLa) with intense green emission and a low cytotoxicity profile, indicating the potential real-time application of 1[PF6] as a pH-responsive AIEgen in the future.
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