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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...

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Related Experiment Video

Updated: May 13, 2026

Combined In vivo Optical and &#181;CT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
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Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice

Published on: October 16, 2014

Microstructural electromechanical coupling changes in bone under sepsis.

Chaojun Tang1, Yichen Xing1, Jinxi Tian1

  • 1School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.

Journal of Biomechanics
|May 11, 2026
PubMed
Summary
This summary is machine-generated.

Bone

Keywords:
BoneElectromechanical couplingMicroscaleScanning probe microscopySepsis

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Related Experiment Videos

Last Updated: May 13, 2026

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A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

Area of Science:

  • Biomaterials Science
  • Bone Biology
  • Mechanobiology

Background:

  • Type I collagen fibrils are crucial for bone's mechanical integrity and mechanotransduction.
  • The piezoelectric properties of collagen are vital for bone remodeling.
  • Changes in collagen's electromechanical coupling during sepsis are not well understood.

Purpose of the Study:

  • To investigate the temporal changes in mechanical and piezoelectric properties of type I collagen fibrils in rat cortical bone during mild sepsis.
  • To understand the evolution of electromechanical coupling in bone during disease progression.

Main Methods:

  • Scanning probe microscopy (SPM) was employed to quantitatively assess individual type I collagen fibrils.
  • Young's modulus and piezoelectric amplitude were measured at various time points post-sepsis induction.
  • Fibril diameter, D-periodicity, and mechanical heterogeneity were also analyzed.

Main Results:

  • A biphasic mechanical response was observed: Young's modulus initially decreased then recovered.
  • The piezoelectric response showed an inverse trend to the mechanical response.
  • Significant changes, including reduced diameter and D-periodicity, occurred at 48 hours post-surgery, marking an inflection point.

Conclusions:

  • Sepsis induces a time-dependent decoupling of electromechanical behavior in type I collagen fibrils.
  • These microscale changes offer insights into bone pathophysiology during sepsis.
  • Findings may inform early diagnosis and therapeutic interventions for septic bone disease.