Related Experiment Video
Updated: May 13, 2026
09:58
Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
Protein glycoxidation in neuropsychiatric disorders-from basic research to clinical practice
Wiktor Orlof1, Mateusz Maciejczyk2
1Department of Psychiatry, The Faculty of Medicine, Medical University of Bialystok, 2 Wolodyjowskiego Street, Bialystok, 15-272, Poland.
Redox Biology
|May 11, 2026
Summary
Protein glycation and carbonyl stress are key in neurodegenerative diseases like Alzheimer's and Parkinson's. Current research focuses on indirect modulation and biomarkers, with limited direct antiglycation drugs available.
Area of Science:
- Neuroscience
- Biochemistry
- Pharmacology
Background:
- Protein glycation, glycoxidation, and carbonyl stress are implicated in neurodegenerative and neuropsychiatric disorders.
- These processes are recognized as common features across conditions like Alzheimer's disease (AD), Parkinson's disease (PD), schizophrenia, and depression.
Purpose of the Study:
- To review current findings on protein glycation, glycoxidation, and carbonyl stress in neuropsychiatric disorders.
- To explore mechanistic pathways, clinical relevance, biomarker development, and antiglycation interventions.
Main Methods:
- Literature review integrating current research findings.
- Focus on mechanistic pathways and clinical relevance in selected disorders.
- Analysis of biomarker potential and therapeutic strategies.
Main Results:
- Advanced glycation end products (AGEs), such as CEL and CML, show potential as biomarkers for neurodegenerative diseases.
- Most research focuses on indirect modulation of carbonyl stress and AGE-RAGE signaling, not direct antiglycation activity.
- No current neuropsychiatric drugs demonstrate direct in vivo antiglycation effects.
Conclusions:
- Modulation of protein glycation, carbonyl stress, and AGE-RAGE signaling is a shared mechanistic target in neuropsychiatric disorders.
- AGEs (CEL, CML) may serve as diagnostic/prognostic biomarkers, requiring further validation.
- Development of direct antiglycation therapies for neuropsychiatric conditions remains a challenge.
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