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Updated: May 13, 2026
Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
Published on: July 10, 2014
Injectable amyloid-structured hydrogel incorporating amorphous calcium phosphate promotes periodontal tissue
Kaining Yu1, Yichen Li1, Xuewen Li1
1Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No.12 Qixiangtai Road, Heping District, Tianjin, 300070, China; Tianjin Medical University Institute of Stomatology, No.12 Qixiangtai Road, Heping District, Tianjin, 300070, China.
Abstract:
Periodontitis is the leading cause of tooth loss in adults. Inspired by the role of enamel matrix proteins (EMPs) in promoting periodontal regeneration in vivo and the β-sheet-rich structure of their main component, amelogenin (Am), we developed an amyloid fibril-based hydrogel composed of bovine serum albumin (BSA), reduced glutathione (GSH), and amorphous calcium phosphate (ACP). Within this system, the self-assembled amyloid fibril network of BSA serves as a biomimetic scaffold. GSH plays a dual role by acting as a mild reducing agent that induces protein phase transition and gelation, while also stabilizing ACP through Ca2+ coordination. We propose that this multifunctional system partially recapitulates key structural and ionic features associated with EMP-mediated periodontal regeneration, thereby promoting periodontal repair without the need for exogenous growth factors.
