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Conclusions
1Pediatric Neurosurgical Service, Woman, Mother, Child Hospital, Rockefeller Medical School, Lyon, France. carmine.mottolese@chu-lyon.fr.
Advances and Technical Standards in Neurosurgery
|May 11, 2026
Summary
Multidisciplinary collaboration has significantly improved outcomes for pineal tumours. Advances in diagnostics, endoscopic biopsy, and surgical techniques enhance treatment strategies and patient survival for these rare brain tumours.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Pediatric Oncology
Background:
- Pineal tumours are rare and complex, necessitating a multidisciplinary approach for optimal patient outcomes.
- Recent advancements in diagnostic workup, including tumour markers, enable more precise treatment strategies.
- Multidisciplinary collaboration has led to improved cure rates and reduced long-term side effects for pineal tumours.
Purpose of the Study:
- To review the current advancements in the diagnosis and treatment of pineal tumours.
- To highlight the role of multidisciplinary collaboration in improving patient outcomes.
- To discuss the evolving surgical and adjuvant therapeutic strategies for pineal tumours.
Main Methods:
- Review of recent literature on pineal tumour diagnosis and treatment.
- Emphasis on advancements in diagnostic techniques, including endoscopic biopsies and tumour markers.
- Discussion of surgical modalities like microsurgery, endoscopy-assisted surgery, and exoscopes.
- Exploration of biomolecular and genetic studies for prognostic stratification.
- Consideration of adjuvant therapies such as Gamma Knife radiosurgery, chemotherapy, and radiotherapy.
Main Results:
- Endoscopic techniques are increasingly used for biopsy, particularly in paediatric patients, allowing simultaneous treatment of intracranial hypertension.
- Aggressive surgical resection is a cornerstone for benign pineal tumours, with improved outcomes due to advanced surgical techniques and neuro-anaesthesiology.
- Biomolecular and genetic studies have identified prognostic groups for pinealoblastomas, enabling tailored treatment intensification or de-escalation.
- Gamma Knife radiosurgery can be an adjuvant or alternative treatment but requires caution due to radionecrosis risk, especially in children.
Conclusions:
- Multidisciplinary collaboration, advanced diagnostics, and refined surgical techniques have significantly improved outcomes for pineal tumours.
- Personalized treatment strategies based on histology, biomolecular, and genetic markers are crucial for optimizing survival and reducing complications.
- International registries are essential for a better understanding of pineal tumour natural history and treatment outcomes.
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