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Conclusions.

Carmine Mottolese1

  • 1Pediatric Neurosurgical Service, Woman, Mother, Child Hospital, Rockefeller Medical School, Lyon, France. carmine.mottolese@chu-lyon.fr.

Advances and Technical Standards in Neurosurgery
|May 11, 2026
PubMed
Summary
This summary is machine-generated.

Multidisciplinary collaboration has significantly improved outcomes for pineal tumours. Advances in diagnostics, endoscopic biopsy, and surgical techniques enhance treatment strategies and patient survival for these rare brain tumours.

Keywords:
ChemotherapyComplementary treatment for pineal tumoursGamma Knife surgeryPineal lesionsPineal region lesions

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Area of Science:

  • Neuro-oncology
  • Neurosurgery
  • Pediatric Oncology

Background:

  • Pineal tumours are rare and complex, necessitating a multidisciplinary approach for optimal patient outcomes.
  • Recent advancements in diagnostic workup, including tumour markers, enable more precise treatment strategies.
  • Multidisciplinary collaboration has led to improved cure rates and reduced long-term side effects for pineal tumours.

Purpose of the Study:

  • To review the current advancements in the diagnosis and treatment of pineal tumours.
  • To highlight the role of multidisciplinary collaboration in improving patient outcomes.
  • To discuss the evolving surgical and adjuvant therapeutic strategies for pineal tumours.

Main Methods:

  • Review of recent literature on pineal tumour diagnosis and treatment.
  • Emphasis on advancements in diagnostic techniques, including endoscopic biopsies and tumour markers.
  • Discussion of surgical modalities like microsurgery, endoscopy-assisted surgery, and exoscopes.
  • Exploration of biomolecular and genetic studies for prognostic stratification.
  • Consideration of adjuvant therapies such as Gamma Knife radiosurgery, chemotherapy, and radiotherapy.

Main Results:

  • Endoscopic techniques are increasingly used for biopsy, particularly in paediatric patients, allowing simultaneous treatment of intracranial hypertension.
  • Aggressive surgical resection is a cornerstone for benign pineal tumours, with improved outcomes due to advanced surgical techniques and neuro-anaesthesiology.
  • Biomolecular and genetic studies have identified prognostic groups for pinealoblastomas, enabling tailored treatment intensification or de-escalation.
  • Gamma Knife radiosurgery can be an adjuvant or alternative treatment but requires caution due to radionecrosis risk, especially in children.

Conclusions:

  • Multidisciplinary collaboration, advanced diagnostics, and refined surgical techniques have significantly improved outcomes for pineal tumours.
  • Personalized treatment strategies based on histology, biomolecular, and genetic markers are crucial for optimizing survival and reducing complications.
  • International registries are essential for a better understanding of pineal tumour natural history and treatment outcomes.