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Related Concept Videos

Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
Diffusion01:12

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
Diffusion01:21

Diffusion

Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
Drug Absorption Mechanism: Passive Membrane Transport01:23

Drug Absorption Mechanism: Passive Membrane Transport

Passive transport is a method of drug absorption where small, lipid-soluble drugs can move across the cell membrane. This movement happens along the concentration gradient, which is a natural flow from higher to lower concentration areas. The speed at which the drug moves is directly related to its lipid–water partition coefficient. This means that the more a drug dissolves in lipids, the faster it diffuses or spreads throughout the body. It is important to note that most drugs are either weak...
Facilitated Diffusion01:16

Facilitated Diffusion

The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting their diffusion into...

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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Published on: October 17, 2013

Lateral Transport in Anisotropic Membrane during Permeation Study in Diffusion Cell.

Patcharawan Nimmansophon1, S Kevin Li2,3

  • 1Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, 45267, USA.

Pharmaceutical Research
|May 11, 2026
PubMed
Summary

Edge effect in membrane transport studies increases flux due to lateral diffusion. This phenomenon, significant in anisotropic membranes, impacts In Vitro Permeation Test (IVPT) data interpretation.

Keywords:
anisotropicdiffusion cellin silicosimulationtransport

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Area of Science:

  • Membrane transport phenomena
  • Computational modeling in biophysics

Background:

  • Mass transport in diffusion cells is complex, involving lateral diffusion.
  • Anisotropic diffusion in biological membranes like skin can cause edge effects, increasing flux.

Purpose of the Study:

  • To evaluate the impact of edge effect in membrane transport.
  • To investigate edge effect under anisotropic diffusion conditions using simulations.

Main Methods:

  • Utilized COMSOL Multiphysics for simulations.
  • Modeled membrane transport with varying lateral and transverse diffusion coefficients.

Main Results:

  • Edge effect caused a 4% to 10% increase in steady-state flux.
  • Increased lateral diffusion coefficients and smaller diffusion cell openings amplified the edge effect.

Conclusions:

  • Edge effect is evident in anisotropic membranes and small diffusion cells.
  • Consideration of edge effect is crucial for accurate In Vitro Permeation Test (IVPT) data interpretation.