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An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
Published on: December 3, 2020
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Permeability of Buccal Mucosa
Apipa Wanasathop1, Priya B Patel1, Hyojin A Choi1
1Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 231 Albert Sabin Way, MSB # 3005, Cincinnati, OH 45267, USA.
Pharmaceutics
|November 27, 2021
Summary
Buccal drug delivery offers advantages, but permeability data is scattered. This review analyzes buccal mucosa permeability, revealing insights into lipoidal and polar transport pathways for optimized drug delivery systems.
Area of Science:
- Pharmacology
- Biomaterials Science
- Drug Delivery
Background:
- The buccal mucosa presents a promising alternative route for drug administration.
- Existing research on buccal drug delivery lacks a comprehensive review of permeability data.
- Understanding the buccal barrier is crucial for effective drug formulation and delivery optimization.
Purpose of the Study:
- To review and analyze buccal mucosa permeability data.
- To investigate the transport pathways governing drug permeation across the buccal mucosa.
- To provide insights for optimizing buccal drug delivery systems.
Main Methods:
- Compilation and review of intrinsic permeability coefficients for porcine buccal mucosa.
- Analysis of permeability data using a model with parallel lipoidal and polar transport pathways.
- Correlation analysis of permeability coefficients with permeant properties (e.g., octanol/water partition coefficient, molecular weight).
Main Results:
- Significant variability was observed in published buccal permeability data.
- A lipoidal pathway correlated permeability with partition coefficients and molecular weight, indicating lower lipophilicity than octanol.
- A polar pathway and macromolecule transport correlated permeability with molecular weight, suggesting an effective pore radius of 1.5–3 nm.
Conclusions:
- Buccal drug permeation involves distinct lipoidal and polar pathways.
- The buccal barrier's properties can be characterized by pore size and lipophilicity.
- This analysis provides a foundation for designing effective buccal drug delivery systems.
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