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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: May 13, 2026

Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells
07:55

Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells

Published on: June 21, 2019

Exploring drug mechanisms through single-cell proteomics.

Yuzhi Sun1, Renjie Liu1,2, Jichong Mu1,2

  • 1Faculty of Computing, Harbin Institute of Technology, Harbin, China.

British Journal of Pharmacology
|May 12, 2026
PubMed
Summary
This summary is machine-generated.

Single-cell proteomics (SCP) offers high-resolution drug discovery by directly measuring proteins, overcoming limitations of bulk omics. This approach enhances target identification and precision therapy development.

Keywords:
drug mechanismssingle‐cell mass spectrometrysingle‐cell proteomicssingle‐cell sequencing

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Single-Cell Proteomics Preparation for Mass Spectrometry Analysis Using Freeze-Heat Lysis and an Isobaric Carrier
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Single-Cell Proteomics Preparation for Mass Spectrometry Analysis Using Freeze-Heat Lysis and an Isobaric Carrier

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Related Experiment Videos

Last Updated: May 13, 2026

Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells
07:55

Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells

Published on: June 21, 2019

Single-Cell Proteomics Preparation for Mass Spectrometry Analysis Using Freeze-Heat Lysis and an Isobaric Carrier
06:13

Single-Cell Proteomics Preparation for Mass Spectrometry Analysis Using Freeze-Heat Lysis and an Isobaric Carrier

Published on: December 9, 2022

Area of Science:

  • Proteomics
  • Drug Discovery
  • Cellular Biology

Background:

  • Traditional bulk omics methods mask cellular heterogeneity, limiting mechanistic insights in drug discovery.
  • Single-cell proteomics (SCP) directly quantifies proteins, providing a high-resolution view of cellular functions and drug responses.

Purpose of the Study:

  • To review the advancements and applications of single-cell proteomics in drug discovery.
  • To highlight SCP's advantages over transcriptomics for understanding drug mechanisms.
  • To discuss the integration of AI with SCP for future drug development.

Main Methods:

  • High-sensitivity mass spectrometry for protein quantification at the single-cell level.
  • Data-independent acquisition techniques enabling proteome-wide analysis.
  • Direct measurement of drug targets, post-translational modifications, and pathway activation.

Main Results:

  • SCP enables direct quantification of thousands of proteins per cell.
  • Demonstrates unique advantages in capturing drug-target interactions and pathway dynamics.
  • Translational applications include target discovery, understanding drug resistance, and advancing precision medicine.

Conclusions:

  • Single-cell proteomics represents a paradigm shift from transcriptomics to proteomics for drug discovery.
  • SCP offers unparalleled resolution for analyzing drug action and cellular heterogeneity.
  • The integration of AI with SCP promises to revolutionize protein-centered drug discovery.