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MOGAD optic neuritis post enterovirus meningitis: a new association
Salman Aljarallah1, Othman O Aldraihem2, Khalid Alqarni1
1Neurology Unit - Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Enterovirus meningitis may trigger myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), a rare autoimmune disorder. This case highlights the need to consider post-infectious demyelination after viral meningitis.
Area of Science:
- Neurology
- Immunology
- Infectious Diseases
Background:
- Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare autoimmune demyelinating disorder.
- Common presentations include optic neuritis and transverse myelitis.
- Viral triggers are known, but enterovirus meningitis association is not well-documented.
Purpose of the Study:
- To report a case of MOGAD following enterovirus meningitis.
- To highlight a potential, under-documented trigger for MOGAD.
Main Methods:
- Case report of a 17-year-old female.
- Diagnosis of enterovirus meningitis confirmed by CSF PCR and MRI.
- Diagnosis of MOGAD confirmed by positive MOG-IgG and clinical presentation.
- Treatment with intravenous steroids.
Main Results:
- The patient presented with enterovirus meningitis.
- Subsequently developed optic neuritis.
- Confirmed MOGAD with positive MOG-IgG.
- Achieved full recovery after steroid treatment.
Conclusions:
- Enterovirus meningitis may be a trigger for MOGAD.
- Post-infectious demyelination should be considered in neurological symptoms post-viral meningitis.
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