Increasing Dietary Quercetin Intake Reduces Stroke Risk and Improve Long-Term Survival in Chronic Kidney Disease...

Quercetin has anti-inflammatory properties. This study aims to explore the association between dietary quercetin intake, stroke risk, and long-term survival in chronic kidney disease (CKD) patients. The analysis included 2001 CKD participants from National Health and Nutrition Examination Survey (NHANES) 2007-2010 and 2017-2018, with a weighted total population of 25,005,023. A weighted logistic regression model, restricted cubic splines (RCS) curve, weighted COX proportional hazards model, subgroup analysis, and Kaplan-Meier curve were constructed to comprehensively analyze the relationship between dietary quercetin intake and stroke prevalence as well as long-term survival. At the same time, propensity score matching (PSM) was used to reduce the influence of confounding factors. After adjusting for all covariates, for every 1 mg/day increase in dietary quercetin intake, the prevalence of stroke decreases by 4% (OR = 0.96, 95% CI: 0.92-1.00). The RCS curve indicates that the protective effect of dietary quercetin intake on the prevalence of stroke is a linear relationship. Moreover, subgroup analysis indicated that the protective effect of dietary quercetin intake on the prevalence of stroke might be achieved by reducing inflammation. Meanwhile, for every 1 mg/day increase in dietary quercetin intake, the mortality decreases by 2% (HR = 0.98, 95% CI: 0.96-1.00). This observational cohort study showed that increased dietary quercetin intake is associated with reduced stroke risk and increased long-term survival in CKD patients. It is necessary to recommend increasing dietary quercetin intake as a supplementary treatment for CKD patients.