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Related Concept Videos

Ultrasonography01:17

Ultrasonography

Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called a...
Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):

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Related Experiment Video

Updated: May 14, 2026

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
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Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Published on: August 14, 2012

New Frontiers in Contrast-Enhanced Ultrasound for Cancer Imaging.

Felipe Matias Berg1,2, Michaela Briana Cooley3, Theresa Kosmides3

  • 1Department of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, United States.

ACS Nano
|May 12, 2026
PubMed
Summary

Nanobubbles (NBs) offer advanced cancer imaging and therapy potential beyond current microbubbles. Engineered NBs can target tumors and improve ultrasound contrast, but require further development for clinical use.

Keywords:
contrast mediaearly diagnosisinterventional radiologymicrobubblesmolecular imagingmultimodal imagingnanobubblesnanoparticlesneoplasmsultrasonography

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Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension

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Last Updated: May 14, 2026

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
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Published on: December 5, 2020

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Nanobubbles (NBs) are emerging as advanced ultrasound contrast agents for cancer diagnostics and therapeutics.
  • Unlike larger microbubbles confined to vasculature, NBs can access perivascular and extravascular tumor regions.
  • NBs feature tunable shells (polymeric, lipid, hybrid) for enhanced stability, circulation, and targeted delivery via surface functionalization.

Purpose of the Study:

  • To review recent advancements in nanobubble design and functionalization for oncology.
  • To summarize key preclinical applications of nanobubbles in cancer imaging and therapy.
  • To discuss translational challenges and priorities for nanobubble clinical integration.

Main Methods:

  • Review of preclinical studies on nanobubble applications in various cancer models.
  • Analysis of nanobubble engineering strategies for improved targeting and imaging.
  • Discussion of formulation, acoustic optimization, and safety considerations for clinical translation.

Main Results:

  • Nanobubbles demonstrate potential for extended ultrasound imaging, enhanced sensitivity, and improved tumor-to-background ratios.
  • NBs can be functionalized for receptor-directed binding and combined with other imaging modalities (optical, MRI).
  • Preclinical data supports nanobubbles' utility across diverse cancer types.

Conclusions:

  • Nanobubbles show significant promise as next-generation cancer imaging and therapeutic agents.
  • Overcoming challenges in acoustic optimization, manufacturing, and safety is crucial for clinical translation.
  • Further development is needed to integrate nanobubbles into precision oncology workflows.