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Stereolithographic 3D Printing with Renewable Acrylates
Published on: September 12, 2018
Antimicrobial DMAHDM nanoparticle-modified resin for 3D printing: Composition-Property relationships.
Gan Jin1, Yunqi Liu1, Dae Gyun Lee2
1Department of Prosthodontics, College of Dentistry, Yonsei University, Seoul, 03722, Republic of Korea.
Summary
This study shows that adding dimethylaminohexadecyl methacrylate (DMAHDM) nanoparticles to urethane acrylate (UA)-based 3D-printing resin enhances antibacterial and antifungal properties. The resin demonstrates potential for dental applications with improved conversion and biocompatibility.
Area of Science:
- Biomaterials Science
- Dental Materials
- Nanotechnology
Background:
- 3D printing resins are increasingly used in dentistry.
- Developing resins with antimicrobial properties is crucial for preventing oral infections.
- Dimethylaminohexadecyl methacrylate (DMAHDM) nanoparticles show promise for antimicrobial applications.
Purpose of the Study:
- To investigate the impact of varying DMAHDM nanoparticle concentrations in UA-based 3D-printing resins.
- To evaluate the effects on antibacterial and antifungal activities, biocompatibility, degree of conversion (DC), and mechanical properties.
- To determine the optimal DMAHDM proportion for enhanced resin performance in potential dental applications.
Main Methods:
- Synthesized UA-based resin and DMAHDM nanoparticles separately.
- Prepared specimens with DMAHDM concentrations ranging from 0-1 wt%.
- Assessed antibacterial activity against Streptococcus mutans using WST-8 assay.
- Evaluated antifungal activity against Candida albicans via OD600 measurements.
- Determined biocompatibility using human gingival fibroblasts (WST-8 and EdU assays).
- Analyzed degree of conversion (DC) using FTIR spectroscopy.
- Measured flexural strength, flexural modulus, and Vickers hardness.
Main Results:
- Antibacterial efficacy against S. mutans increased with DMAHDM concentration, significantly reducing bacterial viability.
- Antifungal activity against C. albicans showed a dose-dependent inhibition.
- No cytotoxicity was observed, though cell proliferation decreased with higher DMAHDM content.
- The highest DC was achieved at 1 wt% DMAHDM.
- Flexural strength and Vickers hardness were highest at 0 wt% DMAHDM, with slight decreases at higher concentrations.
Conclusions:
- DMAHDM-incorporated UA-based 3D-printing resin exhibits significant antibacterial and antifungal effects.
- The resin demonstrates excellent biocompatibility, improved polymer conversion, and competitive mechanical properties.
- These findings highlight the potential of DMAHDM-modified UA resins for advanced dental applications.
