Rising trends in dermatology publications using large-scale databases

The use of large-scale databases in medical research is increasing due to advancements in computing power and ease of execution; however, their practical application in dermatology remains incompletely characterized. We reviewed the number of overall dermatology publications and the use of 14 large-scale databases in dermatology publications during recent decades. We also discussed the ethical implications of the growing use of large-scale databases in medical research, specifically dermatology. Structural issues within large-scale databases potentially introduce bias and risk, exacerbating existing disparities. There are also concerns surrounding data transparency, reproducibility, and integrity. The protection of patient privacy, autonomy, and informed consent, finally, remains a major ethical concern in large-scale database research. Although these database resources allow for expanded research capabilities, there remains limited long-term validation of their findings, along with questions regarding their general limitations.