Related Experiment Video
Updated: May 14, 2026
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Clinical-pathological T-stage discrepancy in OPHL: impact on oncologic outcomes
Carlotta Liberale1, Sara Librio2, Edoardo Serafini3,2
1Department of Otolaryngology Head and Neck Surgery, University Hospital of Modena, Modena, Italy. carlotta.liberale@gmail.com.
Background:
Clinical-pathological discordance in T staging is common in laryngeal squamous cell carcinoma (LSCC) and may affect treatment planning and prognosis. Its impact in patients treated with open partial horizontal laryngectomy (OPHL) remains unclear.
Methods:
A retrospective multicenter study was conducted on 106 patients with glottic or supraglottic LSCC treated with OPHL. Discrepancies between clinical (cT) and pathological (pT) staging were analyzed. Associations with preoperative factors, adjuvant therapy, disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS) were evaluated.
Results:
T-stage discordance was observed in 37.7% of patients, with 19.8% upstaged and 17.9% downstaged. No preoperative factor was significantly associated with discordance. T-stage discrepancy was not significantly associated with DFS, DSS, OS, or the need for adjuvant therapy.
Conclusion:
In patients undergoing OPHL, clinical-pathological T-stage discordance does not appear to significantly affect oncologic outcomes, likely due to the modular and adaptable nature of the surgical procedure.
