Related Experiment Video
Updated: May 14, 2026
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
Immediate Implant-Based Breast Reconstruction: Analysis of 787 Cases and Definition of Our Decision-Making Algorithm
Federico Taraschi1, Liliana Barone Adesi1, Nicole Ratti2
1UO Chirurgia Plastica, Dipartimento per la Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS - Università Cattolica del "Sacro Cuore", Largo Agostino Gemelli 8, 00168, Rome, Italy.
Background:
Immediate implant-based breast reconstruction (IBBR) following nipple-sparing (NSM) or skin-sparing mastectomy (SSM) increasingly requires individualized technique selection. Choosing among prepectoral direct-to-implant (DTI), submuscular DTI, and two-stage expander reconstruction remains complex. This study analyses outcomes from a large single-centre cohort to define a pragmatic, evidence-based decision-making algorithm.
Methods:
A retrospective monocentric review included all consecutive IBBR procedures performed between 2018 and 2024. Patients were allocated to three groups: prepectoral DTI (n = 601), submuscular DTI (n = 142), and two-stage expander reconstruction (n = 44). Demographic, oncologic, and surgical variables were collected. Major complications were evaluated using unadjusted analyses and inverse-probability-of-treatment weighting. A dedicated subgroup analysis was performed for patients receiving postmastectomy radiotherapy (PMRT).
Results:
A total of 1,093 breasts were reconstructed. Weighted analysis showed similar overall major-complication rates for prepectoral and submuscular DTI (7.3% vs 8.4%, p = 0.278), while expanders demonstrated the lowest adjusted risk (0.7%). Within the PMRT subgroup, prepectoral DTI did not show increased infection, dehiscence, or seroma compared with the other techniques; infection was significantly lower than in submuscular DTI (2.7% vs 14.3%, p = 0.020). Capsular contracture was markedly less frequent in prepectoral DTI and remained significantly reduced after multivariable adjustment (OR 1 [reference]; OR 9.03 for submuscular DTI; OR 3.25 for expanders).
Conclusions:
Our resulting algorithm offers a structured, patient-specific approach to optimise outcomes in immediate implant-based breast reconstruction.
Level Of Evidence Iv:
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
