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Updated: May 14, 2026
Syngeneic Mouse Orthotopic Allografts to Model Pancreatic Cancer
Published on: October 4, 2022
Glycosylated Chitosan Inhibits Pancreatic Cancer Metastasis by Blocking the Caveolin Signaling Pathway
Yong Li1,2, Jacob Paul Adams3, Jingxuan Yang4
1Tianjin Key Laboratory of Cancer Prevention and Therapy, Interventional Therapy Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Background And Objectives:
Pancreatic cancer is highly metastatic, and metastasis is the main cause of cancer-related deaths. Therefore, finding methods to inhibit pancreatic cancer metastasis has important clinical value.
Methods:
N-dihydrogalactochitosan (GC) is an immunostimulant that can enhance the anti-tumor immune response to inhibit metastasis in combination with photothermal therapy.
Results:
Here, we found that GC can inhibit the migration of pancreatic cancer cells through interactions with caveolin-1 (Cav-1). The fluorescence of GC-FITC on the cell surface overlaps with Cav-1-Red, is enhanced by adCav-1, and is weakened by siCav-1, indicating that the localization of GC depends on Cav-1. GC inhibits the migration of malignant cells by blocking the signal transduction of Cav-1 and its downstream molecules. In an orthotopic pancreatic tumor model, GC can inhibit tumor metastasis in tumor-bearing mice.
Conclusions:
These results demonstrate GC's capacity to act as a partner in pancreatic cancer therapy and indicate future directions for metastatic cancer therapy.
