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Updated: May 14, 2026

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Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts
Published on: March 26, 2015
Comparing Outcomes of ACL Reconstruction with and Without Cyclic Graft Loading: A Two-Year Minimum Follow-Up Study.
Jérôme Murgier1, Thibaut Tourcher2, Sonja Cabarkapa3
1Clinique Aguiléra-Ramsay Santé, 21 Rue de l'Estagnas, 64200 Biarritz, France.
Journal of Clinical Medicine
|May 13, 2026
Summary
Cyclic graft loading during anterior cruciate ligament (ACL) reconstruction did not significantly impact re-rupture rates or knee laxity in this study. Further research is needed to confirm these findings for ACL surgery outcomes.
Area of Science:
- Orthopedic Surgery
- Sports Medicine
- Biomechanical Engineering
Background:
- The role of cyclic graft loading in anterior cruciate ligament (ACL) reconstruction is not fully established.
- Debate exists regarding its necessity and impact on surgical outcomes.
Purpose of the Study:
- To compare clinical outcomes of ACL reconstruction with versus without intraoperative cyclic graft loading.
- To evaluate the effect of cyclic loading on graft re-rupture rates and knee stability.
Main Methods:
- Retrospective comparative study of 216 patients undergoing ACL reconstruction with hamstring autografts.
- Two groups: cyclic graft loading (n=104) and no cyclic loading (n=112).
- Outcomes assessed: re-rupture rates, knee laxity (Rolimeter®), Lysholm, and IKDC scores at minimum 2-year follow-up.
Main Results:
- No significant difference in re-rupture rates between groups (2.5% vs. 2.9%, p=0.78).
- Similar mean side-to-side laxity differences (1.1 mm vs. 1.2 mm, p=0.39).
- No significant differences in patient-reported Lysholm or IKDC scores.
Conclusions:
- This retrospective study found no statistically significant difference between ACL reconstruction with or without cyclic graft loading.
- Findings suggest cyclic loading may not be essential for comparable outcomes in this cohort.
- Caution is advised due to potential temporal confounding; prospective randomized trials are recommended.