Related Experiment Video
Updated: May 14, 2026
09:04
Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
Natural Products as NLRP3 Inflammasome Inhibitors: A Review
Yiyi Lu1,2,3, Lin Jiang4, Peng Ding2
1School of Pharmacy, Hunan Normal University, Changsha 410081, China.
Molecules (Basel, Switzerland)
|May 13, 2026
Summary
Natural products can inhibit the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome, offering a novel approach for treating chronic inflammatory diseases like diabetes and cardiovascular disorders.
Area of Science:
- Immunology
- Pharmacology
- Natural Products Research
Background:
- The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome is crucial in innate immunity and is activated by danger signals.
- NLRP3 inflammasome activation is implicated in chronic inflammatory conditions such as diabetes mellitus and cardiovascular disorders.
Purpose of the Study:
- To review the literature on natural products that inhibit NLRP3 inflammasome activation.
- To explore the therapeutic potential of these natural products for chronic inflammatory diseases.
Main Methods:
- Literature search using keywords like "NLRP3 Inflammasome", "Natural products", and "Inhibitor".
- Databases searched include CNKI, Google Scholar, PubMed, and Web of Science.
- Review covers literature from 1997 to 2025.
Main Results:
- Herbal remedies demonstrate protective effects against NLRP3 inflammasome activation.
- Natural products offer a novel therapeutic strategy by preventing NLRP3 inflammasome activation.
Conclusions:
- Natural products possess anti-inflammatory properties by inhibiting the NLRP3 inflammasome.
- These findings suggest natural products as a practical therapeutic approach for chronic inflammatory illnesses.
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