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A Scalable Touchscreen-Based Spatial Working Memory Task for Cross-Species Research.

Casey R Vanderlip¹, Shelby R Dunn², Payton A Asch²

¹Department of Neurobiology and Behavior, University of California Irvine.

Biorxiv : the Preprint Server for Biology

|May 13, 2026

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We developed a new touchscreen task for spatial working memory in marmosets and humans. This scalable cognitive paradigm helps study brain function and diseases across species.

Area of Science:

Neuroscience
Cognitive Science
Primate Models

Background:

The common marmoset is a valuable nonhuman primate model in neuroscience.
Development of cognitive tasks for marmosets has not kept pace with neural recording and genetic tools.

Purpose of the Study:

Introduce and validate a touchscreen-based spatial working memory task.
Enable direct cross-species translation between marmosets and humans.
Provide parametric control over memory maintenance and interference demands.

Main Methods:

Developed a Delayed Non-Match-to-Position task using a touchscreen interface.
Systematically varied memory delay (1, 5, 10s) and spatial separation of stimuli.
Tested twelve marmosets and seventy-one human participants.

Keywords:

marmoset nonhuman primate spatial working memory touchscreen translational

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Main Results:

Accuracy decreased with increased delay and decreased spatial separation in both species.
Delay and spatial separation interacted, showing additive effects on performance.
Choice latency analyses supported performance interpretation, with slower responses on incorrect trials.

Conclusions:

Established a scalable, translationally aligned spatial working memory paradigm.
The task captures interacting maintenance and interference processes.
Provides a platform for circuit-level investigation and cognitive assays in marmosets for aging and disease studies.